Exciting news from the Lab

  • Adli lab has been awarded an NSF grant to develop tools to manipulate and image chromatin structure and function (Aug, 2017)

  • Kudos to Cem! CRISPR-STOP is a new cool tool to silence genes by base editing. It is accepted for publication in Nature Methods (May, 2017)

  • Congratulations to all the fantastic team! CRISPR-chromatin imaging in living cell paper is now published in Nature Communications (April, 2017)

  • Adlilab has been awarded an RO1 grant by NCI to study chemoresistance-associated epigenomic aberrations in Ovarian Cancer (April, 2017)

  • Kudos to Ritambhara! The CROP-IT CRISPR off target prediction tool is published in Nucleic Acid Research (June, 2015).

  • Dr. Adli is named 2014 V Scholar , an award from V Cancer research foundation (Oct, 2014).

  • The very first manuscript from the Adlilab has been published in Nature Biotechnology (May, 2014).

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  • The Adli lab is focused on understanding whole-genome level chromatin regulation during normal (Cell, 2013) and disease development. We are specifically focused on understanding aberrant chromatin regulation in cancer progression and chemotherapy resitance Cancer (Cancer Cell, 2012; Nature, 2012, Nature 2011). We are using Genomics and Epigenomics profiling tools such as ChIP-Seq,ATAC-Seq and RNA-Seq to identify disease associated aberrantly regulated genomic region. We then use existing tools and develop novel genome and epigenome profiling and manipulation tools to study epigenetic mechanisms of chromatin structure and function.

    We are using CRIPSR/Cas9 technology (Nature Biotechnology, 2014) and developing novels tools to further improve this exiting technology (Nucleic Acid Research, 2015). We are particularly interested in repurposing it for epigenome editing, chromatin structure manipulation and imaging purposes. We also perform whole genome knock-out screenings to identify novel regulators of cellular state transitions in stem cell differentiation and cancer progression.

    Our lab is located on the 6th floor of Jordan Hall (Room 6228) and we are part of University of Virginia, School of Medicine, Department of Biochemistry and Molecular Genetics.