Dept. of
Chemistry
phone:
(434) 243-2132
P.O. Box 400319
fax:
(434) 924-3710
Positions and Employment
Assistant
Professor, University
of Virginia,
Charlottesville,
VA
July 2005-present
Department of
Chemistry and Neuroscience Graduate Program
Research interests:
· Detection of
dopamine, adenosine, and serotonin
using electrochemical sensors
· Development of
new carbon nanotube-basedbiosensors
· Rapid-sampling
microdialysis with capillary
electrophoresis detection for monitoring
neurotransmitter changes
during
behavior
Postdoctoral
Researcher, University
of Michigan,
Ann
Arbor, MI
2003-2005
Advisors: Robert
Kennedy (Chemistry) and Terry Robinson (Psychology)
Research
topic: Capillary
electrophoresis analysis of microdialysis samples for
the detection
of rapid amino acid changes in the brain
Education
Ph.D.,
Chemistry (Analytical), University
of North Carolina,
Chapel Hill, NC
2003
Advisor: Mark Wightman
Dissertation: Electrochemical
detection of chemical dynamics in the rat brain
B.S.,
Chemistry, University
of Delaware,
Newark,
DE
1998
Honors
degree, summa
cum laude
Research
Advisor: Murray Johnston
Undergraduate thesis: Secondary
structure of oligonucleotides probed by MALDI
Grants and Funding
National
Institutes of Health, National Institute of Biomedical Imaging
and Bioengineering, Aug. 2007-July 2009, $275,000
R21: “An electrochemical adenosine sensor for in vivo applications”
Eli Lilly Young Investigator Award,
Sept. 2007-Sept. 2009, $100,000
National Science Foundation,
Feb. 2007-Jan. 2012, $550,000
“CAREER: Carbon nanotube modified microelectrodes for insect
neurotransmitter detection”
American Heart Association,
July 2007- June 2009, $132,000
“Mechanisms of adenosine formation during ischemia”
Distinguished
Young
Investigator Award, Fund for
Excellence in Science and
Technology, University
of Virginia,
July 1,
2006-June 30, 2007, $50,000
“Monitoring
fast neurochemical changes using
capillary electrophoresis with electrochemical detection”
Jeffress
Memorial
Trust, Jan.
1-Dec.31, 2006, $25,000
“Development
of an electrochemical adenosine sensor”.
Awards
and Fellowships
American Chemical Society PROGRESS/Dreyfus Foundation
Lectureship
2008
Eli Lilly Young Analytical Investigator Award
2007
NSF CAREER award
2007-2012
NIH
Postdoctoral Fellowship
2003-2005
· NIDA
Institutional Training Grant
Charles N. Reilley Award
2002
· Presented
by Pharmacia to the most outstanding analytical graduate student
National
Science Foundation
1998-2001
· Graduate
Research Fellowship
Dobbins
Fellowship, UNC Chemistry
Department
2000
Venable
Fellowship, UNC Chemistry
Department
1998
Eugene
DuPont
scholarship, University
of Delaware
1994-1998
Professional
Memberships
American
Chemical Society
Society
for
Neuroscience
Refereed Publications
Note:
published
under both Venton and Trafton.
From work done at Virginia:
20.) C. B. Jacobs, T.L. Vickrey, and B.J.
Venton. Measuring chemical events in
neurotransmission. In “Encyclopedia of Chemical Biology”, Wiley.
in press (invited)
19.) A.M. Strand and B.J. Venton.
Flame etching enhances the sensitivity of carbon-fiber
microelectrodes. Analytical Chemistry, in press (available
online, DOI: 10.1021/ac8001275)
18.) S. Cechova and B.J. Venton.
Transient adenosine efflux in the rat caudate-putamen. Journal of
Neurochemistry, 2008, 105, 1253-1260. (DOI:
10.1111/j.1471-4159.2008.05223.x)
17.) B.E. Kumara Swamy and B.J. Venton.
Carbon nanotube-modified microelectrodes for simultaneous detection of
dopamine and serotonin in vivo. Analyst, 2007, 132, 876-894.
* This article was highlighted in Chemical Technology, 2007, 4,
T66.
16.) B.E. Kumara Swamy and B.J. Venton.
Subsecond detection of physiological adenosine concentrations using
fast-scan cyclic voltammetry. Analytical Chemistry, 2007, 79,
744-750.
Work Previous to Virginia:
15.) B.J. Venton and R.M.
Wightman. Pharmacologically induced, subsecond dopamine
transients in the caudate-putamen of the anesthetized rat.
Synapse, 2007, 61, 37-39.
14.) B.J. Venton, R.T.
Kennedy, T.E. Robinson, S. Maren. Dynamic increases in glutamate
and GABA in the basolateral amygdala during acquisition and expression
of conditioned fear. European Journal of Neuroscience, 2006, 12,
3391-3398.
13.) B.J. Venton, P.E.M.
Phillips, W.C. Wetsel, D. Gitler, G. Augustine, P. Greengard, R.M.
Wightman. Cocaine increases dopamine release by mobilization of a
synapsin-dependent reserve pool. Journal of Neuroscience, 2006,
26, 3206-3209.
12.) D. Gitler, J. Feng, Y. Takagishi, V.M. Pogorelov, R.M. Rodriguiz, B.J. Venton, P.E.M. Phillips, Y.
Ren, H.-T. Kao, R.M. Wightman, P. Greengard, P, W.C. Wetsel, G.J.
Augustine. Synaptic vesicle trafficking and drug addiction
in synapsin triple knockout mice. Cell Biology of Addiction,
2006, 341-359.
11.) C.J. Watson, B.J. Venton,
R.T. Kennedy. In vivo measurements of neurotransmitters by
microdialysis sampling. Analytical Chemistry, 2006, 78, 1391-1399.
10.) B.J. Venton, T.E.
Robinson, R.T. Kennedy. Transient changes in nucleus accumbens
amino acid concentrations correlate with individual responsivity to the
predator fox odor 2,5-dihydro-2,4,5-trimethylthiazoline. Journal
of Neurochemistry 2006, 96, 236-246.
9.) B.J. Venton, H. Zhang,
P.A. Garris, D. Sulzer, P.E.M. Phillips, R.M. Wightman. Real-time
decoding of dopamine neurotransmission in the caudate-putamen during
tonic and phasic firing. Journal of Neurochemistry, 2003, 87,
1284-1295.
8.) B.J. Venton and R.M.
Wightman. Psychoanalytical electrochemistry: dopamine and
behavior. Analytical Chemistry, 2003, 75, 414A-421A.
7.) D.L. Robinson, B.J. Venton,
M.L. Heien, R.M. Wightman. Detecting subsecond dopamine release
with fast-scan cyclic voltammetry in vivo. Clinical Chemistry,
2003, 49, 1763-1773.
6.) P.A. Garris, E.A. Budygin, P.E.M. Phillips, B.J. Venton, D.L. Robinson, B.P.
Bergstrom, G.V. Rebec, R.M. Wightman. A role for presynaptic
mechanisms in the actions of nomifensine and haloperidol.
Neuroscience, 2003, 118, 819-829.
5.) B.J. Venton, D.J. Michael,
R.M. Wightman. Correlation of local changes in extracellular
oxygen and pH that accompany dopaminergic terminal activity in the rat
caudate-putamen. Journal of Neurochemistry, 2003, 84, 373-381.
4.) K.P. Troyer, M.L. Heien, B.J.
Venton, R.M. Wightman. Neurochemistry and
electroanalytical probes. Current Opinion in Chemical Biology,
2002, 6, 696-703.
3.) B.J. Venton, K.P. Troyer,
R.M. Wightman. Response times of carbon fiber microelectrodes to
dynamic changes in catecholamine concentration. Analytical
Chemistry, 2002, 74, 539-546.
2.) D.L. Robinson, P.E.M. Phillips, E.A. Boudygin, B.J. Trafton, P.A. Garris, R.M.
Wightman. Sub-second changes in accumbal dopamine during sexual
behavior in male rats. NeuroReport, 2001, 12, 2549-2552.
1.) B.D. Bath, D.J. Michael, B.J.
Trafton, J.D. Joseph, P.L. Runnels, R.M. Wightman.
Subsecond adsorption of dopamine at carbon-fiber microelectrodes.
Analytical Chemistry, 2000, 72, 5994-6002.
Book Chapter
M.G. Roper, C. Guillo, and B.J.
Venton. High speed electrophoretic separations. In
“Handbook of Capillary Electrophoresis and Microchip Separations,” CRC
Press, editor: J.P. Landers, 2008. (invited)
Invited Lectures
Eli Lilly &
Company. April 15, 2008
“Electrochemical sensors for detection of rapid neurotransmitter
changes in the fruit fly”
Pittsburgh Conference on Analytical Chemistry, March 3, 2008
“Carbon nanotube electrodes for in vitro and in vivo monitoring of
serotonin release”
Southeast Regional Meeting of the American Chemical Society, Oct. 26,
2007
“Real-time measurements of adenosine in vivo using carbon-fiber
mciroelectrodes”
Federation of Analytical
Chemistry and Spectroscopy Societies (FACSS), Oct. 15, 2007
“Increasing the sensitivity of carbon-fiber microelectrodes for in vivo
applications”
University
of Virginia, Molecular Physiology
and Biophysics Seminar Series, Oct. 8, 2007.
“Real-time detection of neurotransmitter changes: Applications for
dopamine, serotonin, and adenosine measurements”
University of North Carolina, Wightman Symposium, July 21, 2007.
“Increasing the sensitivity of carbon fiber microelectrodes for in vivo
applications”
University of Virginia, Dept. of Anesthesiology Seminar Series, May 8,
2007
“Microelectrodes for studying rapid neurochemical changes: Applications
for adenosine, dopamine and serotonin measurements.”
University of Virginia, Neuroscience Seminar Series, April 3,
2007
“Sensing and sampling techniques for measuring dynamic changes of
neurotransmitters in vivo”
Pittsburgh Conference on Analytical Chemistry, Feb 28, 2007
“Carbon nanotube modified microelectrodes for rapid determination of
neurochemical changes”,
Wake Forest University, Dept. of Chemistry, Feb. 8, 2006
“High speed separations for detection of fast neurochemical changes
during behavior.”
Accepted Invitations for
Upcoming Lectures
Purines 2008, June 2008
Monitoring Molecules in vivo,
Vancouver, Canada, Aug. 2008
Selected Contributed Conference Presentations
M. Huffman and B.J. Venton.
Comparison of Different Carbon Fiber Kinetics by Fast-Scan Cyclic
Voltammetry, Pittsburgh Conference on Analytical Chemistry, 2008.
S. Cechova and B.J. Venton.
Detection of adenosine concentration changes with carbon
microelectrodes using fast-scan cyclic voltammetry in striatum of
anesthetized rats, Society for Neuroscience Meeting, 2007.
X. Borue, S.E. Cooper, B. Condron, B.J.
Venton. Rapid detection of extracellular dopamine levels
in the fruit fly, Society for Neuroscience Meeting, 2007.
B.M. Kile, B.J. Venton, George
Augustine, R. Mark Wightman. Evaluation of calcium dependent
dopamine release in synapsin triple knockout mice. Society for
Neuroscience Meeting, 2007.
B.E. Kumara Swamy and B.J. Venton.
Rapid monitoring of adenosine concentrations with fast-scan cyclic
voltammetry, Pittsburgh Conference on Analytical Chemistry, 2007.
B.J. Venton and
B.E. Kumara
Swamy. Development
of a carbon-fiber microelectrode sensor for sub-second detection of
adenosine
concentrations. Society for
Neuroscience Meeting, 2006.
B.J. Venton,
T.E.
Robinson, R.T. Kennedy, S.E.
Maren. Transient
changes in glutamate
and GABA release during acquisition and expression of conditioned fear. Society
for Neuroscience Meeting, 2005.
B.J. Venton, T.E. Robinson,
R.T. Kennedy. Fast
changes in amino acid neurotransmitters are correlated with stress
behaviors: A
microdialysis with online capillary
electrophoresis study. Pittsburgh
Conference on Analytical Chemistry, 2005.
B.J. Venton,
T.E.
Robinson, R.T. Kennedy. Monitoring
fast changes in amine
neurotransmitters using microdialysis with on-line capillary
electrophoresis
detection. American Chemical
Society National Meeting,
Aug. 2004 (invited).
B.J. Venton, C.J.
Watson,
A.-N. Samaha, T.E.
Robinson, R.T. Kennedy. Monitoring
amine
neurotransmitters in freely-moving rats using microdialysis with
on-line
capillary electrophoresis detection.
American Chemical Society Central
Regional
Meeting, 2004 (invited).
B.J. Venton,
P.E.M.
Phillips, D. Gitler, W.C.
Wetsel, G.J. Augustine, R.M. Wightman.
Cocaine enhances dopamine release through mobilization of
a
synapsin-sensitive pool. Society
for Neuroscience Meeting, 2003.
B.J. Venton,
R.M. Wightman. Correlation
of
extracellular oxygen and pH
changes in the rat caudate-putamen. Society
for Neuroscience Meeting, 2002.
B.J. Venton,
R.M. Wightman. Dopamine
diffusion in the brain measured by amperometry. Pittsburgh
Conference on Analytical
Chemistry, 2002.
B.J. Trafton, E.A.
Boudygin, P.E.M. Phillips,
D.L. Robinson. The
pharmacodynamics of
cocaine and GBR 12909: effect on evoked dopamine release measured by
fast scan
cyclic voltammetry in vivo. Society
for Neuroscience Meeting, 2000.
updated
4/20/08
©
All
materials on this webpage are the
property of The Venton Research Group
